Comparison of muscle force after immediate and delayed reinnervation using nerve-muscle-endplate band grafting

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Nerve-muscle-endplate band grafting: a new technique for muscle reinnervation..

BACKGROUND Because currently existing reinnervation methods result in poor functional recovery, there is a great need to develop new treatment strategies. OBJECTIVE To investigate the efficacy of our recently developed nerve-muscle-endplate band grafting (NMEG) technique for muscle reinnervation. METHODS Twenty-five adult rats were used. Sternohyoid (SH) and sternomastoid (SM) muscles serve...

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Reinnervation of denervated muscle by implantation of nerve‐muscle‐endplate band graft to the native motor zone of the target muscle

INTRODUCTION Motor endplate reinnervation is critical for restoring motor function of the denervated muscle. We developed a novel surgical technique called nerve-muscle-endplate band grafting (NMEG) for muscle reinnervation. METHODS Experimentally denervated sternomastoid muscle in the rat was reinnervated by transferring a NMEG from the ipsilateral sternohyoid muscle to the native motor zone...

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Selective cricothyroid muscle reinnervation by muscle-nerve-muscle neurotization.

OBJECTIVE To determine if selective reinnervation of the cricothyroid muscle could be achieved with muscle-nerve-muscle neurotization. DESIGN Case series. SETTING Tertiary referral center. PATIENTS Three consecutive patients with high vagal lesions that resulted in unilateral laryngeal paralysis. INTERVENTIONS Patients underwent laryngeal reinnervation with ansa hypoglossi to recurrent ...

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Reinnervation of motor endplate-containing and motor endplate-less muscle grafts.

Damaged muscle fibers degenerate and are phagocytosed, but their connective tissue sheaths and myogenic cells survive. New myofibers regenerate within the connective tissue sheath and functional reinnervation is restored. The present study compared regenerating myofibers and their reinnervation in muscle grafts where the original motor endplates were removed and when they were present. In regen...

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Bioengineered nerve regeneration and muscle reinnervation.

The peripheral nervous system has the intrinsic capacity to regenerate but the reinnervation of muscles is often suboptimal and results in limited recovery of function. Injuries to nerves that innervate complex organs such as the larynx are particularly difficult to treat. The many functions of the larynx have evolved through the intricate neural regulation of highly specialized laryngeal muscl...

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ژورنال

عنوان ژورنال: Journal of Surgical Research

سال: 2013

ISSN: 0022-4804

DOI: 10.1016/j.jss.2012.02.055